BS EN ISO 23196:2023

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Water quality. Calculation of biological equivalence (BEQ) concentrations

Published By	Publication Date	Number of Pages
BSI	2023	26

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Categories: 13.060.70 - Examination of biological properties of water, BSI

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This document specifies the derivation of biological equivalence (BEQ) concentrations for results of in vitro bioassays which are based on measuring effects on a biological process such as enzyme induction or cellular growth. The concept described here can be used for any biological assay after the proof of its applicability. To derive BEQ concentrations, the effect on a biological process caused by a sample – i.e. the activity of the sample – is expressed in terms of a concentration of a reference compound which results in an equivalent effect on the process. The term “sample” used in this document addresses environmental samples as well as defined mixtures and pure compounds used as test item in a bioassay. BEQ concentrations can be derived for environmental water samples, extracts of environmental water samples including tap water or solutions of pure chemicals or mixtures of chemicals.

PDF Catalog

PDF Pages	PDF Title
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11	5.1 General 5.2 Procedure for the calculation of biological equivalence (BEQ) concentrations 5.2.1 Assessment of the suitability of the experimental data for the calculation of a biological equivalence (BEQ) concentration
14	5.2.2 Fitting of concentration-effect data for the reference compound
15	5.2.3 Calculation of quality measures for the fit
16	5.2.4 Normalization of data from the reference compound and samples
17	5.2.5 Calculation of the x %-effect level of the reference concentration-effect relationship and the respective RCx-value
18	5.2.6 Assessment of the validity of the experimental data for the calculation of a biological equivalence (BEQ) concentration 5.2.7 Calculation of the concentration factor of the sample at x %-effect level by linear interpolation
19	5.2.8 Calculation of the biological equivalence (BEQ) concentration